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Cancer cells use an aging gene to establish permanent footing Researchers at the University of Helsinki and the Beatson Institute for Cancer Research in Glasgow have discovered how mutated cells promote their chances to form cancer. Typically, the accumulation of harmful cells is prevented by active competition between multiple stem cells in intestinal glands, called crypts. The functioning of intestinal stem cells relies on growth factors, named Wnts, produced by the surrounding environment. Intestinal cancers typically originate from stem cells where mutations allow growth independent of these factors. When we removed a gene called Notum, which renders Wnts inactive, from mutated stem cells, the number of precancerous adenomas in the intestine was greatly reduced. We found that mutated cells use this gene to block environmental factors critical to normal stem cells gaining advantage in competition.

Eteläuomen läiPekka katajistoNalle pentinmikkoEmily hendersonUniversity of helsinkiBeatson institute for cancer research in glasgowBeatson instituteCancer researchAssistant professor pekka katajistoஎமிலி ஹென்டர்சன்பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கிபீட்சன் நிறுவனம் க்கு புற்றுநோய் ஆராய்ச்சி இல் கிளாஸ்கோபீட்சன் நிறுவனம்புற்றுநோய் ஆராய்ச்சி