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On November 16, 1906, American doctor Richard Strong injected a muddy-looking liquid into the arms of twenty-four inmates at the Bilibid Prison in the Philippines. Strong did not tell the men what was inside these hypodermic syringes, and those who resisted the injection were urged on by prison guards.
Strong wanted to test the side effects of a popular cholera vaccine. He wasn’t particularly invested in protecting the health of his subjects; he was hoping to prove that his own vaccine was more effective than others. Three days after the procedure, two of the inoculated men fell ill and died. Autopsies suggested an unexpected culprit: the bubonic plague. By the time the disease had run its course, thirteen of the twenty-four inmates were dead.