Scientists Link Rare Genetic Phenomenon to Neuron Function, Schizophrenia
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Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study
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Patrick F. Sullivan, PhD
A new $8 million NIH grant seeks to uncover more clues into what genes increase the risk of developing schizophrenia.
Greg Crawford, Charlie Gersbach, Tim Reddy and Raluca Gordân from the Duke Center for Genomic and Computational Biology have teamed up with Patrick Sullivan, Yun Li, Michael Love, and Paola Giusti-Rodriguez at UNC-Chapel Hill and Flora Vaccarino at Yale University to narrow down areas of the genome previously marked relevant to schizophrenia risk.
“Schizophrenia is incredibly complex at every level,” Sullivan said, “from DNA to its clinical manifestations.”
Previous genetic studies -some piloted by Sullivan – have narrowed down the search space. Using samples from 25,000 patients who had schizophrenia and 97,000 samples from those who didn’t, researchers discovered 270 different regions of interest in the genome. These regions vary in size, but each on average span hundreds of thousands of base pairs.