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Report of Independent Registered Public Accounting Firm To the Board of Directors of Aeglea BioTherapeutics, Inc. Opinion .

United statesCompany ability toSeriesa preferred stock of the companyDevelopment expensesPublic accounting firmExchange commissionParapyre holdingParty transactionsBoard of directors aeglea biotherapeutics incSpyre incFairmount funds managementCompany board of directorsSpyre therapeutics incAeglea biotherapeutics incDeposit insurance corporationIndependent registered public accounting