For the first time, scientists have decoded the genomes of those older than 100 years in their quest to find out how centenarians avoid age-related diseases and survive longer than most people.
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Researchers have discovered that people who live more than 105 years likely have a special genetic background that makes their bodies more capable of repairing DNA, according to a new study.
People who live for more than 105 years tend to have a unique genetic background that makes their bodies more efficient at repairing DNA, a study has found.
Researchers compared the sequenced genomes of 81 Italians aged 105 and over with healthy adults from the same region that were aged around 68.
They found that certain genetic changes, which were linked to DNA repair, cellular health and the death of damaged cells, were more common in people aged over 105.
The team said that the study represents the first time that the genomes of people with extreme longevity have been decoded in such fine detail.
People Aged Over 105 may Have More Efficient DNA Repair by Angela Mohan on May 5, 2021 at 8:54 AM
eLife.
These people have had their genomes decoded in a detailed manner first time, providing clues as to why they live so long.br> Aging is a common risk factor for several chronic diseases and conditions, explains Paolo Garagnani, Associate Professor at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy, and a first author of the study. We chose to study the genetics of a group of people who lived beyond 105 years old and compare them with a group of younger adults from the same area in Italy, as people in this younger age group tend to avoid many age-related diseases and therefore represent the best example of healthy aging.