Palleon Pharmaceuticals : Presents Data Suggesting Role of Hypersialylation in Metastatic Melanoma Patients Resistance to PD1 Inhibitors
04/09/2021 | 12:02am EDT
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Palleon Pharmaceuticals, a company pioneering the field of glycan-mediated immune regulation to treat cancer and inflammatory diseases, today announced the presentation of data supporting the role of hypersialylation in the immune escape of metastatic melanoma at the AACR Annual Meeting held virtually April 10-15, 2021.
The research, conducted in collaboration with Massachusetts General Hospital, used Palleon’s HYDRA technology to quantify immunosuppressive sialoglycans of melanoma tumor samples. The tumor tissue had been surgically removed from patients with stage IV melanoma (n=54) who had had zero to four prior rounds of immunotherapy treatment, prior to their initiation of treatment with a PD1 inhibitor. Hypersialylation of tumor cell-surface glycans is known to correlat
Search jobs 09-Apr-2021 Palleon Pharmaceuticals Presents Data Suggesting Role of Hypersialylation in Metastatic Melanoma Patients’ Resistance to PD1 Inhibitors
WALTHAM, Mass. (BUSINESS WIRE) Palleon Pharmaceuticals, a company pioneering the field of glycan-mediated immune regulation to treat cancer and inflammatory diseases, today announced the presentation of data supporting the role of hypersialylation in the immune escape of metastatic melanoma at the AACR Annual Meeting held virtually April 10-15, 2021.
The research, conducted in collaboration with Massachusetts General Hospital, used Palleon’s HYDRA technology to quantify immunosuppressive sialoglycans of melanoma tumor samples. The tumor tissue had been surgically removed from patients with stage IV melanoma (n=54) who had had zero to four prior rounds of immunotherapy treatment, prior to their initiation of treatment with a PD1 inhibitor. Hypersialylation of tumor cell-sur
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Palleon Pharmaceuticals, a company pioneering the field of glycan-mediated immune regulation to treat cancer and inflammatory diseases, today announced the appointment of Nikola Trbovic, Ph.D., Executive Director and Partner at Pfizer Ventures, as a member of its Board of Directors.
“Nikola’s expertise in R&D and corporate finance will be an asset to Palleon, and we are very pleased to welcome him to the Board. Nikola will replace Bill Burkoth, who we would like to thank for the valuable support and guidance that he has given to Palleon over the years,” said Jim Broderick, M.D., Chief Executive Officer and Founder of Palleon. “This is an exciting time of growth for the company as our lead program, an enzymatic sialoglycan degrader for T cell exhaustion in cancer, is expected to enter clinical testing later this year. We look forward to working closely with Nikola as we advance our programs to first