How to Know If You re Maximizing Your mAb Recovery
High concentration mAb formulations and their properties
Image credit: Pall Corporation
Having first emerged as therapeutics in the 1980s, monoclonal antibodies (mAbs) are the predominant class of recombinant biologic drugs in development.
While intravenous (IV) infusion is a frequently utilized administration route for mAbs, for patients requiring a frequent dosing regimen, subcutaneous delivery (sub-C) in doses between 1-1.5 mL is now preferred as it supplies the possibility of self-treatment by utilizing pre-filled syringes
2.
mAbs are usually required to be prepared at concentrations that are higher than 100 g/L and up to 250 g/L
Freeze Thawing as Part of End-to-End Solutions
Sponsored Content by Pall CorporationApr 29 2021
An end-to-end solution is a completely functional solution delivering a self-contained service, system, or process stage from start to finish. Individual components are typically sourced and managed through a single supplier within a fully integrated solution.
Image Credit: Pall Corporation
By focusing supply on a single point of ownership, this type of solution has the benefit of decreasing supply chain risk. It is for this reason that a fully integrated process can become a trusted partnership between supplier and drug manufacturer.
As part of an end-to-end solution, integration is about bridging gaps and connecting processes efficiently whilst considering the full life cycle of any pharmaceutical product. When freezing drug substances, process disconnection often happens just before freezing when downstream processing is complete.
Improving the Productivity of Steam Cracking Furnaces and Improving Their Emissions Control
Sponsored by Pall CorporationApr 21 2021
Hydrocarbon streams leading to ethylene steam cracking furnaces often contain considerable levels of corrosive products, water and salts. Contaminants in the inlet hydrocarbons can severely impact ethylene production in a number of ways.
Image credit: kalyanby/shutterstock.com
Sodium and iron oxides are known to be coke promoters, and when present, they can inhibit the run time of the ethylene furnaces before decoking is necessary, and in some cases, diminish the life of the furnace tubes by as much as one third.
Unplanned or frequent decoking cycles results in ethylene production loss, reduced furnace tube life and leads to increased maintenance costs. Frequent decoking will also result in more particulates being released into the atmosphere and can generate real environmental concerns over excessive emissions.
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