With just 22 minutes into the encounter, Mbokani put the visitors ahead with Aurelio Buta providing the assist. Left unmarked in the hosts’ goal area, the 35-year-old controlled a pass from the Portuguese midfielder before slotting past Burkina Faso international Herve Koffi.
Their lead was threatened after Maxime Le Marchand was given his marching orders with four minutes left into the half-time break. Following a dangerous tackle on Hamdi Harbaoui, referee Jan Boterberg had no option but to send him off.
Despite their numerical disadvantage, they doubled their advantage through Mbokani in the 48th minute. With Didier Ze dribbling his markers in the box, he teed up the African star who rolled the ball into an empty net.
Mbokani s brace powers 10-man Royal Antwerp past Olinga s Royal Excel Mouscron goal.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from goal.com Daily Mail and Mail on Sunday newspapers.
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Rangers scored two late goals last week to take a slender lead into Thursday s reverse fixture and extended their lead inside nine minutes through Alfredo Morelos strike en route to a 9-5 aggregate victory.
Lior Refaelov added to his goal and two assists from the first leg by equalising for Antwerp in Glasgow, but substitute Patterson - given a reprieve by Gerrard after his recent breach of coronavirus protocols - made an instant impact to put the Gers back in front.
Ryan Kent gave the hosts more breathing space nine minutes later and although Didier Lamkel Ze pulled one back another for Antwerp, Borna Barisic and Cedric Itten netted late penalties as Rangers reached the last 16 for the second year running.