Bisiayo Fashemi, PhD, discusses how the addition of entinostat to olaparib could help combat PARP inhibitor-resistance in homologous recombination proficient ovarian cancer, as well as the clinical significance of utilizing mouse organoid models to investigate such strategies.
A team led by Masaya Hagiwara of RIKEN national science institute in Japan has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques.
In this second episode of OncChats: Taking Organoids From Bench to Bedside Through Endoscopy in Pancreatic Cancer, Toufic A. Kachaamy, MD, Madappa Kundranda, MD, PhD, and Richard Burkhart, MD, provide an overview of patient-derived organoids and pharmacotyping in locally advanced pancreatic cancer.
Drs Burkhart, Kundranda, and Kachaamy discuss the involvement of the gastroenterologist from diagnosis to palliative care in the management of patients with pancreatic cancer.
3D patient-derived tumor organoids hold great potential for many basic and translational applications. However, traditional approaches to organoid image analysis and downstream data processing are often challenging and labor-intensive. Download this presentation to discover how Dr. Christophe Deben, Group Leader of the University of Antwerp’s Tumoroid Screening Lab, has developed a label-free brightfield image analysis software (OrBITS) to monitor organoid growth rates and track movement