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Testing the limits of generative AI

As part of the learning curve with AI and LLMs, experiment all you want, but take the results with some skepticism, especially if you’re using it to write your code.

The complete sequence of a human Y chromosome

The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure that includes long palindromes, tandem repeats and segmental duplications1–3. As a result, more than half of the Y chromosome is missing from the GRCh38 reference sequence and it remains the last human chromosome to be finished4,5. Here, the Telomere-to-Telomere (T2T) consortium presents the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference, showing the complete ampliconic structures of gene families TSPY, DAZ and RBMY; 41 additional protein-coding genes, mostly from the TSPY family; and an alternating pattern of human satellite 1 and 3 blocks in the heterochromatic Yq12 region. We have combined T2T-Y with a previous assembly of the CHM13 genome4 and mapped available population variation, clinical

OPINION | SA is the world s most unequal country – a key moment in fintech can help change that

AI in banking and fintech goes back decades, but shot back into the headlines in 2022 with the boom in generative AI. Digital financial services veteran Christo Davel sees this cultural moment as an unmissable opportunity to create a more financially free society.

Managing Hybrid Teams - ACM Queue

Managing Hybrid Teams - ACM Queue
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