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Background: Delirium is associated with serious adverse health outcomes, particularly increased intensive care unit (ICU) stay and mortality rate. Critical care nurses lack sufficient knowledge about delirium and it remains undetected and poorly managed. Aim: In this protocol, the development, implementation and evaluation of the INDICATION (INnovative DelIrium CAre educaTION) program on delirium care knowledge, confidence, competence and clinical practice among critical care nurses in Taiwan is reported. Methods: A quasi-experimental trial will be performed to examine the effects of the INDICATION program. This study will be conducted at a teaching hospital in Taiwan. Two ICUs will provide the sites to recruit critical care nurses to participate. The INDICATION program for the intervention group will be delivered as a multi-modal delirium care education intervention consisting of: (1) one face-to-face education session; (2) five online delirium care learning modules; and (3) simulatio