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SunRISe-1 and NURE-COMBO: Addressing Unmet Needs and Expanding Treatment Options for Bladder Cancer

Neal Shore, MD, FACS, discusses how the SunRISe-1 trial design addresses the need for bladder-sparing treatment options for patients with BCG-unresponsive high-risk non-muscle-invasive bladder cancer (HR NMIBC) who are ineligible for or refuse radical cystectomy. He also contrasts the treatment approach and outcomes observed in the NURE-COMBO trial with the current standard neoadjuvant chemotherapy plus radical cystectomy regimen for muscle-invasive bladder cancer (MIBC), discussing how this chemoimmunotherapy combination may potentially expand treatment options for this patient population.

Novel therapies demonstrate promising efficacyBladder cancerAddressing unmet needsExpanding treatment options

Novel Therapies for Bladder Cancer: Safety Profiles and Study Design Considerations

Neal Shore, MD, FACS, discusses the safety profiles reported across the nadofaragene firadenovec, SunRISe-1, and NURE-COMBO trials, highlighting any unexpected toxicities observed with these novel therapies for non-muscle-invasive and muscle-invasive bladder cancer. Additionally, he reviews key limitations of the study designs or patient populations that may impact the interpretation and generalizability of the results from these trials.

Novel therapies demonstrate promising efficacyBladder cancerSafety profilesStudy design

NURE-COMBO: Patient Population, Regimen, and Efficacy in MIBC

NURE-COMBO: Patient Population, Regimen, and Efficacy in MIBC
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Novel therapies demonstrate promising efficacyBladder cancerPatient population

Novel Therapy + 5-Year Bladder Preservation for Patients with NMIBC

Novel Therapy + 5-Year Bladder Preservation for Patients with NMIBC
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Novel therapies demonstrate promising efficacyBladder cancerYear bladder preservation

Comparing Long-Term Efficacy of Bladder-Preserving Therapies for NMIBC

Comparing Long-Term Efficacy of Bladder-Preserving Therapies for NMIBC
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Novel therapies demonstrate promising efficacyBladder cancerLong term efficacyBladder preserving therapies