Molecule Associated With Poor Survival After Heart Attack Detected by Karishma Abhishek on March 14, 2021 at 7:08 AM
Heart failure is one of the deadly heart diseases, affecting 6.2 million Americans and mandates new therapies. It is an incurable disease with a staggering mortality rate of 40% within five years of diagnosis.
Reducing the levels of a heart molecule, G protein-coupled receptor kinase 5 (GRK5) may promise a novel therapeutic strategy against heart failure as per a study at the Lewis Katz School of Medicine (LKSOM) at Temple University in new work, published in the journal Cardiovascular Research. Previous studies had found that GRK5 is elevated in patients with heart failure. Our new research, in mice that experienced a myocardial infarction (heart attack), shows that GRK5 overexpression is associated with physiological changes in the heart that decrease cardiac function , says Claudio de Lucia, MD, Ph.D., an associate scientis