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Johns Hopkins Develops Method to Detect Cancer from Junk DNA

Johns Hopkins Develops Method to Detect Cancer from Junk DNA
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Capturing immunotherapy response in a blood drop

Capturing immunotherapy response in a blood drop
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Liquid biopsies could be used as an early marker of immunotherapy response, study finds

Liquid biopsies are blood tests that can serially measure circulating tumor DNA (cell-free DNA that is shed into the bloodstream by dying cancer cells).

United kingdomNew yorkUnited statesMegan craigNoushin niknafsMark sausenArchana balanBenjamin levyJohns hopkinsJulie brahmerValsamo elsa anagnostouAstra zenecaBristol myers squibbJay campbellJohns hopkins kimmel cancer centerUs national institutes of health

Tumor Immunotherapy Response May be Predicted by Hard-To-Lose Mutations

A subset of mutations, termed persistent mutations, could help predict immunotherapy responses.

Noushin niknafsValsamo anagnostouJohns hopkinsBloomberg kimmel institute for cancer immunotherapyJohns hopkins kimmel cancer centerTechnology networkLung cancer precision medicine centerKimmel instituteJohns hopkins molecular tumor boardCancer genome atlasJohns hopkins kimmel cancerCancer genome

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

Noushin niknafsValsamo anagnostouJohns hopkinsEmily hendersonBloomberg kimmel institute for cancer immunotherapyJohns hopkins kimmel cancer centerLung cancer precision medicine centerKimmel instituteJohns hopkins molecular tumor boardCancer genome atlasJohns hopkins kimmel cancerAncer immunotherapyHead and neck cancerImmune responseImmune systemLung cancer