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Myelin, a sheath of insulation around nerves that enables electrical impulses to efficiently travel through the central nervous system, is diminished in mice that have a gene deletion associated with autism spectrum disorder, new research finds.
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IMAGE: Noboru Hiroi, PhD, and collaborators are studying which mouse pup cries are most predictive of the pups developing autism spectrum disorder later. Dr. Hiroi is a professor at The University. view more
Credit: The University of Texas Health Science Center at San Antonio
SAN ANTONIO (May 27, 2021) One-fifth of babies who inherit a genetic variant located on chromosome 16 will develop autism spectrum disorder (ASD) by age 3. The variant is called 16p11.2 deletion.
Noboru Hiroi, PhD, of The University of Texas Health Science Center at San Antonio (also referred to as UT Health San Antonio), is studying mice that have this deletion. The team, which includes colleagues from Japan, Ireland and the U.S., is harnessing the power of machine learning to understand which vocalizations of the newborn mouse pups are most predictive of social abnormalities one month later when the pups reach puberty.