And as the final episode the British medical drama, which first premiered in 1999, aired last night, FEMAIL takes a look at where some of the most famous cast members are now.
Holby City bows out with tear-jerker episode featuring NHS tribute and unexpected twist ok.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ok.co.uk Daily Mail and Mail on Sunday newspapers.
Holby City's Nicky McKendrick was left shaken following a shock attack at the hospital, prompting her to make a life-changing decision about baby Juliet.
Following the BBC announcement that Holby City is set to be axed in 2022, FEMAIL takes a look at some of the biggest star names who started out on the show - including Sheridan Smith.