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Nick zito, the bill and melanie gates foundation, and all the other investments, important, in european funding declined over the past several years. It made little difference in the overall, and when those big numbers stayed big, stay significant, do we have a robust pipeline the fourth blood gets funded. You heard it from the lead scientists in policy perspective, and the p 5 strategy. And high vaccine resulting in Southern Africa and thailand, up and 31 , we cant not explore that. And on the slide previously, and other ideas will they work . We dont know. That is why we do the Clinical Trial. Clinical Research Needs investment. All of the work around that structure based design, all of these exciting neutralizing antibodies that have their clever code names for what they are, each of those needs to be pursued and they need to be pursued in a different way than we worked before. How do you translate that novel idea into a Clinical Trial . When you walk the halls of a science meeting

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