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Similarly, in clinical trials one starts with a target – aka primary endpoint. Generally this is the outcome of the trial you want to measure. These outcomes differ based on the kind of trial being planned. E.g. if we were planning a heart failure trial, some outcomes we might..
measure would be : improvement in LV function, improvement in symptom status, hospitalization, to just name a few. In Covid trials, these end points are determined based on the population we are studying, so for mild cases it might be time to recovery, or progression of disease.
Very grateful to @AnnieDuke for her guest appearance on #StartingGreatness. She offers many great lessons for ambitious founders.
Summarizing in the below thread…
1/ There are different types of “games” in business and in life. Some are based almost entirely on skill, like chess. Garry Kasparov will beat me 100 times in a row. Luck won’t rescue me.
Some Games involve lots of chance and uncertainty. More like poker.
2/ If I play the world champion for an entire night, I likely lose my money. But in one hand, I might have a 40% chance of winning.
Startups are more like poker than chess. They involve skill combined with uncertainty and chance across thousands of decisions, big and small.
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Leadership 101: Be a Practitioner, Not Just a Manager!
I learned about leadership & scaling from Sheryl Sandberg. My direct manager for 10+ yrs, we spent countless hours together in weekly 1x1s (she attended religiously), meetings, offsites, dinners, travel, etc. Here are some of the most important lessons I took away from Sheryl:
In one of our early M-team offsites, everyone shared their mission in life. Sheryl described her passion for scaling organizations. She was single-mindedly focused on this purpose and loved everything about scaling. It’s a huge strength to know what you were put on earth to do.
Sheryl implemented critical systems to help us scale – eg 360 perf reviews, calibrations, promotions, refresh grants, PIPs. She brought structure to our management team and board meetings, hired senior people across the company, and streamlined communications up and down the org.