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Alternative splicing in neurodegenerative disease and the promise of RNA-based therapeutic strategies

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -; single-stranded RNAs involved in protein synthesis -; and proteins from the same stretch of DNA, plays an important role in molecular biology.

Lily ramseyDavid nikomUc riverside neuroscience graduate programNational institutes of healthSchool of medicineNeuroscience graduate programSika zhengNature reviews neuroscienceNeurodegenerative diseaseNational institutesSurvival motor neuronSpinal muscular atrophy

What role does alternative splicing play in n

David Nikom, a student in the UC Riverside Neuroscience Graduate Program, and his advisor, Sika Zheng, have written a review in Nature Reviews Neuroscience to discuss emerging research and evidence of the roles of alternative splicing defects in major neurodegenerative diseases. They also summarize the latest advances in RNA-based therapeutic strategies to target these disorders.

United statesPalm desertCoachella valleyDavid nikomNeuroscience graduate programNational institutes of healthPalm desert centerSchool of medicineUniversity of californiaMethod of researchSika zhengNature reviews neuroscienceNeurodegenerative diseaseNational institutesSurvival motor neuronSpinal muscular atrophy

What role does alternative splicing play in n

What role does alternative splicing play in n
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Palm desertUnited statesCoachella valleyDavid nikomMethod of researchNational institutes of healthPalm desert centerSchool of medicineNeuroscience graduate programUniversity of californiaSika zhengNature reviews neuroscienceNeurodegenerative diseaseNational institutesSurvival motor neuronSpinal muscular atrophy

Alternative Splicing s Role in Neurodegenerative Disease

Alternative Splicing s Role in Neurodegenerative Disease
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Coachella valleyUnited statesPalm desertDavid nikomNational institutes of healthPalm desert centerUc riverside neuroscience graduate programSchool of medicineUniversity of californiaNeuroscience graduate programSika zhengNature reviews neuroscienceNeurodegenerative diseaseNational institutesSurvival motor neuronSpinal muscular atrophy

Q&A: What role does alternative splicing play in neurodegenerative disease?

Q&A: What role does alternative splicing play in neurodegenerative disease?
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David nikomUc riverside neuroscience graduate programSchool of medicineNeuroscience graduate programSika zhengNature reviews neuroscienceNeurodegenerative diseaseSurvival motor neuronSpinal muscular atrophyNature reviews