1. Compared to healthy controls, participants with a first episode of schizophrenia had reduced expression of a microglia-associated protein, CSF1R. 2. CSF1R inhibition worsened anxiety behaviors in mice exposed to chronic unpredictable stress. Evidence-rating level: 3 (Average) Psychosocial stress is thought to contribute to the development of schizophrenia, mainly for those with underlying genetic susceptibility.
1. Patients with mild cognitive impairment (MCI) randomized to a combined intervention of aerobic-resistance exercise and computerized cognitive training, had significantly improved cognitive scores compared to control. 2. There was no significant difference in cognitive improvement when comparing interventions with and without Vitamin D supplementation. Evidence Rating Level: 1 (Excellent) For individuals with mild cognitive impairment
Many individuals infected with COVID-19 continue to experience symptoms after recovering from the initial viral infection. Persistent symptoms include neurocognitive and neuropsychiatric symptoms that can interfere with meaningful daily activities and roles. Given the symptom overlap, best practices and evidenced-based techniques for the treatment of concussion/mTBI can inform treatment approaches to manage symptoms and reduce the negative impact of long COVID.
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