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Credit: Marie Bannier-Hélaouët, Hubrecht Institute
Stem-cell-derived organoids that swell up with tears could shed light on the biology of crying and dry-eye disease, suggests a study publishing March 16 in the journal
Cell Stem Cell. Although regenerative therapies using human tear-gland organoids will not be possible anytime soon, these researchers have demonstrated that the organoids can engraft, integrate, and produce mature tear products upon transplantation into mouse tear glands. We hope that scientists will use our model to identify new treatment options for patients with tear-gland disorders by either testing new drugs on a patient s organoids or expanding healthy cells and, one day, using them for transplantation, says senior study author Hans Clevers (@HansClevers) of the Hubrecht Institute.