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Mitochondrial protein structure activates cell s integrated stress response

Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health.

Jie yangMegan craigKelsey baronGabriel landerLuke wisemanDepartment of integrative structuralScripps researchGabriel lander at scripps researchDepartment of molecularLuke wiseman at scripps researchComputational biology at scripps researchNature structuralMolecular biologyIntegrative structuralComputational biologyElectron microscopy

Mitochondrial Structure May Serve as Target for Future Therapeutics for Age-Related Diseases

Mitochondrial Structure May Serve as Target for Future Therapeutics for Age-Related Diseases
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Gabriel landerJie yangKelsey baronBiology at scripps researchScientists at scripps researchLuke wiseman at scripps researchScripps researchNature structuralLuke wiseman

Spider-like mitochondrial structure initiat

Scripps Research scientists discovered the unique molecular structure, which could have implications in age-related diseases like neurodegeneration.

San franciscoUnited statesMartin kampmannXiaoyan guoGiovanni avilesJie yangKelsey baronGabriel landerAnette schneemannWenqian chenLuke wisemanAlberts song of scripps researchScripps researchComputational biology at scripps researchLuke wiseman at scripps researchGabriel lander at scripps research

Spider-like mitochondrial structure initiates cell-wide stress response

Spider-like mitochondrial structure initiates cell-wide stress response
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San franciscoUnited statesAnette schneemannKelsey baronGabriel landerMartin kampmannXiaoyan guoGiovanni avilesJie yangWenqian chenLuke wisemanDepartment of molecularScripps researchDepartment of integrative structuralLuke wiseman at scripps researchAlberts song of scripps research

Spider-Like Mitochondrial Form Triggers Cellular Stress Response

Spider-Like Mitochondrial Form Triggers Cellular Stress Response
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San franciscoUnited statesGiovanni avilesGabriel landerMartin kampmannLuke wisemanJie yangAnette schneemannKelsey baronWenqian chenXiaoyan guoAlberts song of scripps researchDepartment of integrative structuralScripps researchNational institutes of healthDepartment of molecular