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FDA s Failure to Safeguard the Public Resulted in an Irreparable Erosion of Trust
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COVID-19 mRNA Vaccine Contaminated by Mystery DNAs and Truncated mRNAs: Health Implications
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Pulling Back the Curtain: mRNA Lipid Nanoparticle Design Created Potential for Clotting and Triggering Immune Overdrive
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A Deeper Dive Into the Role of Spike Protein in Myocarditis and Blood Clotting After COVID-19 Vaccination
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Objective To estimate the effectiveness of the bivalent mRNA booster vaccines containing the original SARS-CoV-2 and omicron BA.4-5 or BA.1 subvariants as the fourth dose against severe covid-19.
Design Nationwide cohort analyses, using target trial emulation.
Setting Denmark, Finland, Norway, and Sweden, from 1 July 2022 to 10 April 2023.
Participants People aged ≥50 years who had received at least three doses of covid-19 vaccine (that is, a primary course and a first booster).
Main outcome measures The Kaplan-Meier estimator was used to compare the risk of hospital admission and death related to covid-19 in people who received a bivalent Comirnaty (Pfizer-BioNTech) or Spikevax (Moderna) BA.4-5 or BA.1 mRNA booster vaccine as a fourth dose (second booster) with three dose (first booster) vaccinated people and between four dose vaccinated people.
Results A total of 1 634 199 people receiving bivalent BA.4-5 fourth dose booster and 1 042 124 receiving bivalent BA.1 fourth