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 E-Mail The sense of hearing is, quite literally, a molecular tightrope act. Turns out, it involves acrobatics as well. In a paper published in Nature Communications on Feb 8, researchers at Harvard Medical School and Boston Children s Hospital show that a dynamic and delicate connection between two pairs of diminutive protein filaments plays a central role in in hearing. The tension held by these filaments, together called a tip link, is essential for the activation of sensory cells in the inner ear. The team s analyses reveal that the filaments, which are joined end-to-end, work together like trapeze artists holding hands. Their grasp on each other can be disrupted, by a loud noise, for example. But with a two-handed grip, they can quickly reconnect when one hand slips.

United statesDavid coreyMounir koussaEric mulhallAndrew wardDarren yangWesley wongNational institutes of healthHarvard medical schoolNature communications on febBlavatnik instituteNature communicationsBoston childrenBertarelli professorTranslational medical scienceWyss institute