Using cell culture and mouse model approaches, researchers from Tokyo Medical and Dental University (TMDU) have found a novel drug combination that can inhibit tumor growth in oral and esophageal carcinomas. They also identified a potential biomarker that can help predict patient sensitivity to this treatment. These findings provide valuable knowledge for the fight against these deadly cancers and demonstrate a potential new use for drugs currently approved for other diseases.
Leap Therapeutics Announces Publication of DKN-01 Mechanism of Action Data in Molecular Cancer Research
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How Do Prostate Cancer Cells Resist Treatment? by Pooja Shete on December 12, 2020 at 11:44 PM
The study published in
Molecular Cancer Research was conducted by Researchers at University of Georgia.
The two genes identified are ACSL3 and ACSL4 help the cancer cells to grow. According to the research conducted by Houjian Cai, associate professor in the College of Pharmacy and his colleagues, the genes function in an interconnected way.
The Centers for Disease Control (CDC) reported that prostate cancer is the second leading cause of cancer-related deaths among men in the US.
The primary therapy to treat prostate cancer is castration treatment that suppresses the male hormone which helps the cancer cells to grow. This treatment decreases the expression of ACSL3 gene.
Scientist pinpoints genes that promote the growth of prostate cancer cells
Research by a University of Georgia scientist sheds light on how two genes factor into prostate cancer cells becoming resistant to treatment, providing a potential new target for therapeutics.
The two genes, ACSL3 and ACSL4, are from the same family and help cancer cells grow, according to Houjian Cai, associate professor in the College of Pharmacy. He and a team of researchers found that the genes function in an interconnected way, similar to the concept of yin and yang.
Prostate cancer is the second leading cause of cancer deaths among men in the United States, according to the Centers for Disease Control. Castration treatment, the primary therapy used to fight prostate cancer, suppresses the male hormone that helps the cancer grow. With this therapy, expression of the ACSL3 gene typically becomes low, according to Cai.
Exploring how prostate cancer cells resist treatment
December 10, 2020
Research could provide a pathway for prostate cancer therapeutics
Research by a University of Georgia scientist sheds light on how two genes factor into prostate cancer cells becoming resistant to treatment, providing a potential new target for therapeutics.
The two genes, ACSL3 and ACSL4, are from the same family and help cancer cells grow, according to Houjian Cai, associate professor in the College of Pharmacy. He and a team of researchers found that the genes function in an interconnected way, similar to the concept of yin and yang.
Prostate cancer is the second leading cause of cancer deaths among men in the United States, according to the Centers for Disease Control. Castration treatment, the primary therapy used to fight prostate cancer, suppresses the male hormone that helps the cancer grow. With this therapy, expression of the ACSL3 gene typically becomes low, according to Cai.
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