Nature. The findings build on the previous paper and cap a more than 20-year intellectual journey.
From Complexes to Condensates
With Spo11 and its partners finally purified, the scientists could ask how all these proteins interact with one another by studying them in the controlled environment of a test tube. The results were surprising.
“We knew there were 10 proteins total in the cutting process nine other proteins in addition to Spo11,” Dr. Keeney says. “Based on how other cellular enzyme complexes are thought to work, we assumed that these 10 proteins functioned as a discrete, functional unit. But what we show in this paper is that it’s not that way at all.”
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