Kyoto University developed a model microchip using human iPS cells to measure the transport capacity of the membrane proteins and potentially give test animals some respite. This micro-physiological system or MPS is designed to reproduce the mechanisms of glucose reabsorption and drug excretion in the renal proximal tubules in vitro and ex vivo, mimicking human epithelial cells. Results show that glucose uptake and transport are at significantly higher rates through the engineered co-culture tissue than through monocultures
Test Animals Prepare to Hold Their Breath
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Model microchip that uses human iPS cells could reduce need for animal experimentation
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Next milestones in generating artificial organs
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Recreating the Earliest Stages of Life
Scientists generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos
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SAN FRANCISCO, April 23, 2021 /PRNewswire/ In their effort to understand the very earliest stages of life and how they can go wrong, scientists are confronted with ethical issues surrounding the use of human embryos. The use of animal embryos is also subject to restrictions rooted in ethical considerations. To overcome these limitations, scientists have been trying to recreate early embryos using stem cells.
Gladstone scientist Kiichiro Tomoda and his colleagues use stem cells to generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos. Photo: Gladstone Institutes.