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The COVID-19 pandemic that emerged in Wuhan city of China in December 2019 has adversely impacted the health and the economy, society, and other significant spheres of the human environment. The pandemic has severely impacted economic activities, especially the industrial production, transportation, tourism, and hoteling industries. The present study analyses the impact of varying severity of lockdowns of economic activities during various phases of the pandemic on the water quality of the Yamuna river on parameters like pH values, biological oxygen demand, chemical oxygen demand, dissolved oxygen, total suspended solids, and electrical conductivity. The study has found a significant improvement in water quality parameters with closing economic activities during lockdowns. The average levels of concentration of these parameters of water quality were quite low during the lockdown period at 7.26 (pH value), 31.32, 136.07, 7.93, 30.33 mg/l, and 1500.24 µS/cm compared to pre lockdown