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Genetic variants that impact protein binding in immune cells can cause autoimmune diseases Apr 16 2021 Certain genetic variants that cause modified protein binding in immune cells, are also seen in those at high risk of some autoimmune diseases, new research has found.   Scientists from the Wellcome Sanger Institute, Josep Carreras Leukaemia Research Institute in Spain, and the MRC London Institute of Medical Sciences (LMS) found that certain genetic variants, which alter the binding ability of a protein called PU.1 in neutrophils, are also found to be associated with auto immune disease susceptibility. This new study, published in Nature Communications (16 April 2021), builds on previous research called BLUEPRINT. BLUEPRINT revealed how variation in blood cells’ characteristics and numbers can affect a person’s risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, coeliac disease and type 1 diabetes.

Comunidad autonoma de catalunaMikhail spivakovStephen wattBiola maria javierreSanger instituteNature communicationsLondon institute of medical sciencesWellcome sanger instituteJosep carreras leukaemia research instituteGene control groupMedical sciencesFunctional gene control groupAutoimmune diseaseCoeliac diseaseEne expressionHeart disease