Exploring Endothelial Cell Transformation in Cancer Progression
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Unique inhibitory protein may suppress the formation of cancer cells
Researchers from Tokyo Medical and Dental University (TMDU) identify a novel role for a protein, vasohibin-1, in preventing cancer cells from spreading
Cancer often becomes more difficult to treat and has a poorer prognosis when it spreads throughout the body. This process, called metastasis, is promoted by various cellular events not only become uncontrolled via mutations in cancerous cells, but also by the effects from many types of cells surrounding cancer.
One such event is tumor angiogenesis - the abnormal development of new blood vessels in near solid cancers, causing cancer gets worth. Now, researchers at Tokyo Medical and Dental University (TMDU) have recently discovered a unique inhibitory function of a protein that may help suppress the formation of these tumor vessels in cancer tumors.
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IMAGE: VASH1 exerts anti-angiogenic effects through the inhibition of receptor endocytosis by ?Y-tubulin increases. VEGF and FGF2 induce endocytosis of their own receptors, VEGFR2 and FGFR1, respectively, along MTs. This is. view more
Credit: Department of Biochemistry,TMDU
Researchers from Tokyo Medical and Dental University (TMDU) identify a novel role for a protein, vasohibin-1, in preventing cancer cells from spreading
Tokyo, Japan - Cancer often becomes more difficult to treat and has a poorer prognosis when it spreads throughout the body. This process, called metastasis, is promoted by various cellular events not only become uncontrolled via mutations in cancerous cells, but also by the effects from many types of cells surrounding cancer. One such event is tumor angiogenesis - the abnormal development of new blood vessels in near solid cancers, causing cancer gets worth. Now, researchers at Tokyo Medical and Dental University (TMDU) have recently discove