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Strategy to Prevent Cancer Therapy Resistance Identified

Strategy to Prevent Cancer Therapy Resistance Identified
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Israel generalComunidad autonoma de catalunaSergio espinosa gilMiguel lizcanoManuel lizcanoSergio espinosaHospital del mar research instituteDepartment of biochemistryBiomedical research in gynecologyInstitute of neurosciencesHebron research instituteUniversitat autResearchers josProtein kinasesMolecular biologyCell death

Study identifies strategy to avoid resistance to cancer therapy

Study identifies strategy to avoid resistance to cancer therapy
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Israel generalComunidad autonoma de catalunaMiguel lizcanoManuel lizcanoSergio espinosaSergio espinosa gilInstitute of neurosciencesHebron research instituteHospital del mar research instituteAutonomous university of barcelonaBiomedical research in gynecologyDepartment of biochemistryCell deathProtein kinasesMolecular biologyUniversitat aut

Study identifies a new therapeutic strategy to tackle endometrial cancer

Inhibition of the ERK5 protein kinase reduces the proliferation and survival of endometrial cancer cells, and potentiates standard chemotherapy.

Israel generalComunidad autonoma de catalunaMiguel lizcanoEmily hendersonBiomedical research in gynecologyMolecular life sciencesInstitute of biomedical research lleida irblleidaInstitute of neurosciencesDepartment of biochemistryProtein kinases in cancer researchHebron research instituteProtein kinasesCancer researchMolecular biologyUniversitat autBiomedical research

Researchers identify new mechanism that impairs cancer cell proliferation and induces death

UAB and Vall d'Hebron researchers identified the mechanism by which inhibitors of the ERK5 protein kinase impair the proliferation of cancer cells and induce their death. The results, obtained using human cancer cell lines, demonstrate that ERK5 inhibition activates cytotoxic autophagy, a process that triggers cancer cell death, without affecting healthy cells. A combination of ERK5 inhibitors and chemotherapy could improve cancer treatment.

Israel generalComunidad autonoma de catalunaMiguel lizcanoEmily hendersonHebron researchUnfolded protein responseUniversitat autCell proliferationCancer treatmentEll death