(1) Background: Changes in phospholipid (phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine, i.e., PC, PE and PS) composition with age in the mitochondrial and microsomal membranes of the human cerebellum and motor cortex were examined and compared to previous analyses of the prefrontal cortex, hippocampus and entorhinal cortex. (2) Methods: Nano-electrospray ionization on a hybrid triple quadrupole–linear ion trap mass spectrometer was used to analyse the brain regions of subjects aged 18–104 years. (3) Results: With age, the cerebellum showed many changes in the major phospholipids (>10% of the phospholipid class). In both membrane types, these included increases in PE 18:0 22:6 and PS 18:0 22:6, decreases in PE 18:0 20:4 and PS 18:0 18:1 and an increase in PC 16:0 16:0 (microsomal membrane only). In addition, twenty-one minor phospholipids also changed. In the motor cortex, only ten minor phospholipids changed with age. With age, the acyl composition of the
Adrenic-acid
Arachidonic-acid
Docosahexaenoic-acid
Entorhinal-cortex
Ippocampus
Lipidomics
Mass-spectrometry
Microsome
Itochondria
Eurodegeneration
Prefrontal-cortex
investigation, robert mueller s team slipped this otherwise innocuous line in a sentencing memo for the president s former national security adviser michael flynn. quote, flynn s record of military and public service distinguish him from every other person who has been charged as part of the special counsel s investigation. however, senior government leaders should be held to the highest standards. let that last phrase sink in a moment. senior government leaders should be held to the highest standards. folks, flynn s case is a microsome of where some think the investigation could be headed. with last night s sentencing memo, mueller has laid out one, how a senior government leader was being influenced by a foreign power s financial leverage, and two, how a senior government leader then lied about his foreign ties in an attempt to cover them up. mueller notes how flynn not only lied to investigators about his contacts with russia while he was the national security adviser in both before
President
Michael-flynn
Investigation
Sentencing-memo
Bob-mueller
Public-service
Team
Security
Line
Quote
Case
Part