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UK and South African SARS-CoV-2 variants show higher binding affinity to host cell receptor
Public health officials are concerned over new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerging in various parts of the world.
The B.1.1.7 variant was first found in the United Kingdom and found to have the N501Y mutation that allows it to have a faster transmission rate than previous strains.
The B.1.351 variant was detected in South Africa and also has the N501Y genetic mutation observed in B.1.1.7. However, scientists are also concerned over two other genetic mutations K417N and E484K that have shown an ability to evade the immune system. Prior evidence has found the B.1.351 variant resistant to neutralizing antibodies produced from either prior infection or vaccination.
Unique susceptibility to unique Sars-CoV-2 variants and vaccines medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.
January issue of
SLAS (Society for Laboratory Automation and Screening)
Oak Brook, IL - The January edition of
SLAS Discovery features the cover article, Cryo-EM: The Resolution Revolution and Drug Discovery by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris Phillips, Ph.D., from AstraZeneca.
Cryo-EM, a fast-growing technique in the pharmaceutical industry, enables structure determination of sought-after targets such as large multiprotein complexes and membrane proteins that eluded other structural biology methods. The intricate interactions between compounds and proteins are crucial in accelerating the drug discovery process. The cover article reviews how the structural understanding gained through Cryo-EM is influencing drug discovery projects focused on TRP channels, GPCRs, ribosomes and other high value targets.