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New cause identified for metabolic disease that strikes Native Americans: Scientists topple the prevailing explanation for how the incomplete breakdown of a protein causes neurological damage
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Identified: Cause of Metabolic Disease Striking Native Americans
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Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. NAFLD has been difficult to study mainly because we had no good animal model, said corresponding author Dr. Karl-Dimiter Bissig, who was at Baylor during the development of this project and is now at Duke University.
The disease has both genetic and nutritional components, which have been hard to understand in human studies, and murine models until now had not accurately reflected typical characteristics of human livers with the disease.
Part mouse, part human
Closer to human – mouse model more accurately reproduces fatty liver disease
Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant.
A chimeric mouse model of NAFLD. On the left, a microscopy image of H&E-stained chimeric liver sections showing separation of liver cells from human or murine origin. Note that the fatty, white filling inside human cells is not present in the murine cells. On the right, the bar graph quantifies macro- and microvesicular steatosis (the abnormal retention of fat within the cells) in human and murine chimeric liver tissue. Image courtesy of the authors/
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Mouse model closely reproduces human fatty liver disease
A team at Baylor College of Medicine and other institutions has developed a novel mouse model that reproduces many key features of human non-alcoholic fatty liver disease (NAFLD), a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. With this model, researchers have an opportunity to advance the understanding and treatment of this serious condition for which there is no effective therapy. The study appeared in JHEP Reports.
“NAFLD has been difficult to study since we had no good animal model,” said corresponding author Dr. Karl-Dimiter Bissig, who was at Baylor during the development of this project and is now at Duke University.
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