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Re: A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study

Re: A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study
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Dear editorMendelian randomisationErectile dysfunctionSpecific phosphodiesteraseAnnu rev pharmacol toxicolMendelian randomizationCausal inference using genetic variants

Causal effects of lipids, lipoproteins, and other metabolites on blood pressure

The causal effects of lipoprotein particles, lipids, and other metabolites on blood pressure (BP).

Mendelian randomisationUnited kingdomUnited kingdom biobankBlood pressureArterial stiffnessCardiovascular disease

Using Mendelian Randomisation to model the causal effect of cancer on health economic outcomes and to simulate the cost-effectiveness of anti-cancer interventions

Cancer is associated with significant economic impacts. Quantifying the scale of these impacts is challenged by confounding variables that jointly influence both cancer status and economic outcomes such as healthcare costs and quality of life. Moreover, the increasing costs attributed to cancer drug development complicate the cost-effective provision of cancer care.

Padraig dixonUniversity of oxfordMendelian randomisationUnited kingdom biobank

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality | BMC Medicine

Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depression in people of East Asian ancestry. Multiple Mendelian randomisation (MR) methods were used to test the relationship between (a) BMI and (b) waist-hip ratio (WHR) with depression. Firstly, we performed two-sample MR using genetic summary statistics from a recent genome-wide association study (GWAS) of depression (with 15,771 cases and 178,777 controls) in people of East Asian ancestry. We selected 838 single nucleotide polymorphisms (SNPs) correlated with BMI and 263 SNPs correlated with WHR as genetic instrumental variables to estimate the causal effect of BMI and WHR on depression using the inverse-variance weighted (IVW) method. We repeated these analyses stratifying by home location st

United kingdomKadoorie biobankMendelian randomisationEast asianEast asiaUnited statesChina kadoorie biobank

Debate rages on merits, demerits of regular coffee intake

Regular coffee consumption has been in the news for various reasons- the pleasant and the not so pleasant.

United statesTakeshi hashimotoJessical gleasonRitsumeikan universityUniversity of copenhagenInternational association of athletics federationsWorld health organisationLund universityInternational agency for research on cancerAmerican academy of obstetriciansWorking groupInternational agencySouth americanLancet oncologyMendelian randomisationAmerican academy

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