In the CELEST Extension study, the results of which were published in , the researchers looked at the long-term efficacy, safety, and dose response of the immediate-release formulation of upadacitinib (Rinvoq), a JAK-1 inhibitor, in patients with moderate-to-severe Crohn s disease (CD) who were refractory to tumor necrosis factor (TNF) antagonists. A significant number of patients receiving 15-mg upadacitinib achieved clinical remission after 30 months of open-label treatment, suggesting that this dose is effective as a maintenance treatment for long-term use in patients, although one-third of patients lost response at or after week 4 and required dose escalation to 30 mg.
The goals of treating inflammatory bowel disease (IBD) have evolved from merely controlling symptoms to blocking disease progression and improving long-term disease outcomes. In this prospective cohort study, recently published in , Laharie et al.
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Below is the abstract of the article.
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Many patients with Crohn s disease eventually develop complications, resulting in the need for intestinal surgery, which could lead to the formation of either a temporary or permanent stoma.
In this study published in
Clinical Gastroenterology and Hepatology, Blackwell et al. identified that Crohn s disease patients with unreversed temporary and permanent stomas were more likely to start using an antidepressant compared with patients who had surgery without stoma. Stoma formation was also associated with significant psychiatric morbidity.
Based on these results, clinicians should be vigilant about screening for mood disorders and recommending available treatment options to these patients. These data also emphasize the need for integrated mental health approaches, including counseling before and after surgery, stoma support groups, and online communities.