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Previous clinical trials of dual biologic therapies have raised safety issues, but more recent, promising findings from clinical trials and case series have renewed interest in the treatment approach.

City ofUnited kingdomNew yorkUnited statesUniversity of rochesterMelek yalBrian feaganChristopher ritchlinUniversity clinic erlangenClinical immunology research unitAmerican college of rheumatologyFriedrich alexander university erlangenMedscape medicalMultiple mechanismsFriedrich alexander university erlangen nurembergJoint bone