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Treatment with SD-101 distributed via pressure-enabled drug delivery with immune checkpoint inhibition was tolerated and resulted in the depletion of Tregs, M-MDSCs, and M2 macrophages in liver metastases in patients with uveal melanoma.

San diegoUnited statesSapna patelMelanoma fellowship programDepartment of melanoma medical oncologyUniversity of texas md anderson cancer centerUveal melanoma programMelanoma medical oncologyCancer centerEsd 101M mdscsPressure enabled drug delivery2023 sitc annual meetingPhase 1 perio 01 trial