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Credit: Michigan Medicine
ANN ARBOR, Michigan Income level, employment, housing location, medical insurance, education, tobacco and alcohol use, diet and obesity, access to medical care. These are some of the factors causing worse cancer outcomes in people who are Black.
The same factors are also causing worse outcomes from COVID-19 in this population. The similarities between COVID-19 issues and cancer disparities is uncanny, says John M. Carethers, M.D., John G. Searle Professor and Chair of Internal Medicine at Michigan Medicine. In cancer we are seeing in slow motion what has been observed rapidly with COVID - that the same conditions in our society put specific groups at risk for both. If we can fundamentally change socioeconomic inequality, we theoretically could reduce disparities in both diseases, says Carethers, who is a member of the University of Michigan Rogel Cancer Center.
Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead
ANN ARBOR, Michigan By taking a lesson from prostate cancer, researchers now have a promising lead on a treatment for COVID-19.
Two proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, M.D., Ph.D. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers. They also knew that TMPRSS2 was regulated by the androgen receptor.
So when cancer research shut down in the spring, Chinnaiyan s lab turned its attention to the coronavirus. With a grant from the National Cancer Institute, the team used its existing knowledge and resources to determine how TMPRSS2 was regulated in the lungs.