Global access and patient safety in the transition to environmentally friendly respiratory inhalers: the Global Initiative for Asthma perspective thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.
The clinical implementation of pharmacogenetics (the study of how genetics influence
individual variations in drug response) is a key factor in the development of programmes
to prevent adverse drug reactions. Yet pharmacogenetics testing in clinics is still
infrequent and is mainly reactive and focused on analysing a single drug–gene interaction.
Evaluation of the implementation of pharmacogenetics in the real world is necessary.
Only very few pilot studies have used a pharmacogenetics panel strategy to guide drug
therapy, and mostly in patients aged over 65 years in specialised care settings in
the USA.
These updated, long-term data from CROWN show the durable benefit of lorlatinib over
crizotinib in patients with treatment-naive, ALK-positive non-small-cell lung cancer
and support the use of first-line lorlatinib in patients with and without baseline
brain metastases.