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Brain activity optical imaging aided by new implantable tool: Study ANI | Updated: Apr 24, 2021 22:37 IST
Washington [US], April 24 (ANI): A nanophotonic technology was used by a team of researchers to develop a brain-implantable tool that can aid in the optical imaging of brain activity.
The study was published in the journal Neurophotonics. Tools that allow neuroscientists to record and quantify functional activity within the living brain are in great demand. Traditionally, researchers have used functional magnetic resonance imaging techniques, but this method cannot record neural activity with high spatial resolution or in moving subjects.
In recent years, a technology called optogenetics has shown considerable success in recording neural activity from animals in real-time with single-neuron resolution. Optogenetic tools use light to control neurons and record signals in tissues that are genetically modified to express light-sensitive and
New implantable tool images brain activity in 3D
Tools that allow neuroscientists to record and quantify functional activity within the living brain are in great demand. Traditionally, researchers have used techniques such as functional magnetic resonance imaging, but this method cannot record neural activity with high spatial resolution or in moving subjects.
In recent years, a technology called optogenetics has shown considerable success in recording neural activity from animals in real time with single neuron resolution. Optogenetic tools use light to control neurons and record signals in tissues that are genetically modified to express light-sensitive and fluorescent proteins. However, existing technologies for imaging light signals from the brain have drawbacks in their size, imaging speed, or contrast that limit their applications in experimental neuroscience.
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IMAGE: Optical microscope image of the implantable shanks (141 micron pitch) of a light sheet neural probe. Light is emitted by nanophotonic gratings on the shanks to form light sheets. view more
Credit: Sacher et al., doi 10.1117/1.NPh.8.2.025003.
Tools that allow neuroscientists to record and quantify functional activity within the living brain are in great demand. Traditionally, researchers have used techniques such as functional magnetic resonance imaging, but this method cannot record neural activity with high spatial resolution or in moving subjects. In recent years, a technology called optogenetics has shown considerable success in recording neural activity from animals in real time with single neuron resolution. Optogenetic tools use light to control neurons and record signals in tissues that are genetically modified to express light-sensitive and fluorescent proteins. However, existing technologies for imaging light signals from the brain have drawbacks