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Genetica poate juca un rol în determinarea imunității la COVID-19
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Genetics May Play Role in Determining Immunity to COVID-19
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Neutralizing antibodies develop within two weeks of a SARS-CoV-2 infection, but their durability and intensity can vary by individual, prompting concerns about the prospects of long-lasting immunity and efficacy of COVID-19 vaccines.
In a
PLOS ONE paper, published online February 11, 2021, researchers at University of California San Diego School of Medicine report that individual immune response to SARS-CoV-2, the virus that causes COVID-19, may be limited by the major histocompatibility complex or MHC, a set of variable genes that code for cell surface proteins essential for the adaptive immune system.
Specifically, senior authors Maurizio Zanetti, MD, professor of medicine, Hannah Carter, PhD, associate professor of medicine and colleagues examined how the MHC interacts with two kinds of lymphocytes or immune cells called T and B.