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Acalabrutinib Yields Long-Term Efficacy in a Pooled Analysis of Higher-Risk CLL

Treatment with acalabrutinib-based regimens led to long-term benefits in patients with higher-risk CLL, across all lines of therapy.

United statesDana farber cancer instituteMatthews davidsDivision of lymphomaHarvard medical schoolClinical researchDana farber cancer institutePrecision medicine in oncologyChronic lymphocytic leukemia

FDA Approval Insights: Pirtobrutunib in Previously Treated CLL/SLL

Dr Davids discusses the FDA approval of pirtobrutinib for patients with previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma.

United statesDana farber cancer instituteAshling wahnerMatthews davidsEli lillyHarvard medical schoolClinical researchCenter at dana farber cancer instituteLive on airOnclive on airApple podcastsGoogle podcastsAmazon musicFda approval of pirtobrutinibPatients with previously treated chronic lymphocytic leukemia small lymphoma

Dr Davids on Treatment With Pirtobrutinib in CLL/SLL With/Without Prior BCL-2 Inhibitor Exposure

Matthew S. Davids, MD, MMSc, discusses key efficacy results from 2 follow-up analyses of the phase 1/2 BRUIN trial evaluating pirtobrutinib.

Matthews davidsHarvard medical schoolDivision of lymphomaDana farber cancer institutePhase 1 2 bruin trial nct03740529Irtobrutinib jaypircaHematologic malignanciesRichter transformation

Updated Data from the BRUIN Phase 1/2 Study of Pirtobrutinib in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma Presented at the 2023 ASH Annual Meeting

/PRNewswire/ Eli Lilly and Company (NYSE: LLY) today announced updated clinical data from the international Phase 1/2 BRUIN trial of pirtobrutinib, a.

United statesEli lillyPrnewswire eli lillyKyle owensDavid hymanJoe fletcherMatthews davidsDana farber cancer instituteAmerican society of hematologyLilly united statesLaboratory abnormalitiesExchange commissionAmerican societyAnnual meetingDana farber cancerCommon terminology criteria

MEI Pharma (MEIP) Reports Clinical Data on Oral CDK9 Inhibitor Voruciclib at ASH2023

MEI Pharma (MEIP) Reports Clinical Data on Oral CDK9 Inhibitor Voruciclib at ASH2023
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United statesDavidm ursoMatthews davidsAmerican society of hematologyDivision of lymphomaDana farber cancer instituteClinical researchMei pharma incHarvard medical schoolAmerican societyAnnual meetingOngoing phaseEvaluating voruciclibB cell lymphomaAcute myeloid leukemiaAcute myeloid leukemias