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Updates on Imaging-Based Pancreatic Cancer Surveillance for Individuals With Increased Genetic and Familial Risk

For individuals with known significant familial and/or germline risk factors for pancreatic ductal adenocarcinoma, such data naturally raise the question as to whether surveillance and early detection of PDAC could help improve outcomes from this typically deadly malignancy.

United statesGastrointest endoscCanadian cancer trials groupNational comprehensive cancer networkAmerican society for gastrointestinal endoscopyPancreas screeningImaging based surveillanceAmerican societyGastrointestinal endoscopyEnd resultsNatl cancerPractice guidelinesAmerican cancerPrev resMatthewb yurgelunDana farber cancer institute

Sox9 Protein Enables Molecular Time Travel That Can Lead to Colorectal Cancer

Research from Dana-Farber Cancer Institute looks at what happens before the emergence of mutations that interrupt cellular differentiation in colorectal cancer and finds not only evidence of fetal reprogramming that can initiate cancer, but also a protein, Sox9, that fuels that reprogramming.

Matthewb yurgelunPratyusha balaNilays sethiWilliamc hahnJonathanp rennhackDaulet aitymbayevSethi labSethi lab at dana farberDana farber cancer instituteStudy titleScience advancesFarber cancer instituteColorectal cancer initiation

Sox9 Protein Triggers Colorectal Cancer Time Travel

Sox9 Protein Triggers Colorectal Cancer Time Travel
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Pratyusha balaJonathanp rennhackNilays sethiMatthewb yurgelunWendy coxWilliamc hahnDaulet aitymbayevDana farber cancer instituteNational cancer instituteNational institutes of healthUs department of defenseSethi lab at dana farberHarvard digestive disease centerJimmy fund walk the opiela familySethi labStudy title

Molecular Tumor Board Aids Cancer Precision Medicine

Molecular Tumor Board Aids Cancer Precision Medicine
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Marios giannakisDouglasa rubinsonJonathana nowakLeahh billerStevenm corselloConnor hennesseyThomasa abramsMatthewb yurgelunAndrea ovalleJennifera chanDeborah schragPeterc enzingerVecchio fitzGeoffreyi shapiroBrian wolpinNilay sethi

Online Testing Tool Identifies People Likely to Benefit from Genetic Testing for Inherited Risk for Certain Cancers

Online Testing Tool Identifies People Likely to Benefit from Genetic Testing for Inherited Risk for Certain Cancers
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United statesHolly laducaMiki horiguchiJudye garberSapna syngalHajime unoAmal yussufMatthewb yurgelunC sloane furnissChinedu ukaegbuDana farber genetics programNational institutes of healthDana farber cancer instituteGenetics programCalifornia based ambry geneticsAnu chittenden