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Two Genes in Prefrontal Cortex Implicated in PTSD

Two Genes in Prefrontal Cortex Implicated in PTSD
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Carole liebermanMatthew girgentiSachin patelBeverly hillsJohn krystalYale school of medicineReuters healthPsychiatry at vanderbilt university medical centerYale schoolNew havenNature neuroscienceGeneral psychiatryVanderbilt university medical centerகரோல் லிபர்மேன்சச்சின் படேல்பெவர்லி மலைகள்

Brain tissue analysis may help explain enduring mysteries about PTSD

Brain tissue analysis may help explain enduring mysteries about PTSD A post-mortem analysis of brain tissue from people who had been diagnosed with post-traumatic stress disorder (PTSD) may help explain enduring mysteries about the disorder, such as why women are more susceptible to it and whether a dampened immune system response plays a role in dealing with stress, a team headed by Yale University researchers has found. The analysis of gene expression patterns in brain tissue located in four regions of the prefrontal cortex areas of the brain associated with higher cognitive function and executive control revealed distinct differences in those who had been diagnosed with PTSD and those who had not. Major differences in gene activity particularly affected two cell types in PTSD patients interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report Dec. 21 in the journal

Yale john krystalMatthew girgentiRobertl mcneil jrEmily hendersonYale universityResearch scientistProfessor of translational researchYale department of psychiatryYale departmentStudy leadJohn krystalTranslational researchயேல் ஜான் கிரிஸ்டல்எமிலி ஹென்டர்சன்யேல் பல்கலைக்கழகம்ஆராய்ச்சி விஞ்ஞானி

PTSD seems to be tied to gene expression changes in the brain

PTSD seems to be tied to gene expression changes in the brain Still a ways to go, but it’s an important step. Image via Pixabay. Post-mortem analysis of the brain tissue of patients who had been diagnosed with PTSD are helping us better understand the condition. There’s still a lot we can’t make sense of with PTSD, including why women seem to be more susceptible to it, and whether an impaired immune system plays a part. The brain of the matter The analysis was led by researchers from the Yale University, finding differences in gene expression patterns between patients with PTSD and healthy people in four regions of the prefrontal cortex (PFC). The PFC is associated with higher cognitive functions. These differences affected two types of cells in patients: interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report.

Matthew girgentiJohn krystalYale universityYale department of psychiatryYale departmentஜான் கிரிஸ்டல்யேல் பல்கலைக்கழகம்யேல் துறை ஆஃப் மனநல மருத்துவம்யேல் துறை

Brain tissue yields clues to causes of PTSD

E-Mail A post-mortem analysis of brain tissue from people who had been diagnosed with post-traumatic stress disorder (PTSD) may help explain enduring mysteries about the disorder, such as why women are more susceptible to it and whether a dampened immune system response plays a role in dealing with stress, a team headed by Yale University researchers has found. The analysis of gene expression patterns in brain tissue located in four regions of the prefrontal cortex areas of the brain associated with higher cognitive function and executive control revealed distinct differences in those who had been diagnosed with PTSD and those who had not. Major differences in gene activity particularly affected two cell types in PTSD patients interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report Dec. 21 in the journal

Yale john krystalMatthew friedmanMatthew girgentiRonald dumanRobertl mcneil jrHongyu zhaoYale universityProfessor of translational researchBrain bankUs department of veteransYale department of psychiatryDartmouth universityWhite river junction va medical centerYale departmentJohn krystalTranslational research