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Mini Brain Models Used To Study Alzheimer s and Test Drugs
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The Translational Genomics Research Institute
In the largest study of the associations between smoking and cardiovascular disease on cognitive function, researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, found both impair the ability to learn and memorize; and that the effects of smoking are more pronounced among females, while males are more impaired by cardiovascular disease.
The results appear today in the journal Scientific Reports.
Previous attempts to quantify cognitive function among smokers and assess sex differences produced mixed results. The TGen researchers attribute this to the limited size of previous data sets. By analyzing data representing more than 70,000 individuals worldwide generated through TGen’s online cognitive test called MindCrowd the current study produced results that indicate definitive trends.
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PHOENIX, Ariz. April 13, 2021 Findings of a study by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that increasing expression of a gene known as ABCC1 could not only reduce the deposition of a hard plaque in the brain that leads to Alzheimer s disease, but might also prevent or delay this memory-robbing disease from developing.
ABCC1, also known as MRP1, has previously been shown in laboratory models to remove a plaque-forming protein known as amyloid beta (Abeta) from specialized endothelial cells that surround and protect the brain and cerebral spinal cord. Building on previous studies, TGen conducted a series of pre-clinical genomic laboratory experiments. Results suggest that ABCC1 not only could export Abeta out of the brain, but that increasing the expression of ABCC1 could reduce Abeta production, thus preventing, or delaying, the onset of Alzheimer s.