Scientists to present new findings on protein biochemistry, glycobiology at Life Science Symposium 2021 news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
Read Time:
A particular type of dendritic cell is responsible for the tissue damage that occurs in non-alcoholic steatohepatits (NASH) in mice and humans. The dendritic cells cause aggressive, proinflammatory behavior in T cells, as now discovered by researchers from the German Cancer Research Center (DKFZ) in collaboration with colleagues from Israeli research institutes. Blocking these dendritic cells alleviates symptoms in mice. This type of approach might also prevent the development of serious liver damage in NASH patients.
Obesity is extremely widespread in the Western world, and 90 percent of those affected show signs of fatty degeneration of the liver. If they maintain an unhealthy lifestyle over a long period (high-calorie diet, sedentary lifestyle), liver cell death occurs in around a fifth of these people, resulting in inflammation of the liver, referred to as non-alcoholic steatohepatitis (NASH). NASH can lead to liver fibrosis, life-threatening liver cirrhosis and li
Liver cancer: which patients benefit from immunotherapy? eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
E-Mail
Do BMMFs, the novel infectious agents found in dairy products and bovine sera, play a role in the development of colorectal cancer? Scientists led by Harald zur Hausen detected the pathogens in colorectal cancer patients in close proximity to tumors. The researchers show that the BMMFs trigger local chronic inflammation, which can cause mutations via activated oxygen molecules and thus promote cancer development in the long term. BMMFs and inflammatory markers were significantly more frequently detectable in the vicinity of malignant intestinal tumors than in the intestinal tissue of tumor-free individuals.
A few years ago, scientists led by Ethel-Michele de Villiers at the German Cancer Research Center (DKFZ) discovered a novel form of infectious agents in dairy products and bovine sera. These were ring-shaped DNA elements that showed great similarity to sequences of certain bacterial plasmids. They were named Bovine Meat and Milk Factors (BMMFs) after their origin in b
E-Mail
A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) have now discovered in mice that cells in the so-called stem cell niche are responsible for this: Blood vessel cells of the niche produce a factor that stimulates blood stem cells and thus maintains their self-renewal capacity. During aging, production of this factor ceases and blood stem cells begin to age.
Throughout life, blood stem cells in the bone marrow ensure that our body is adequately supplied with mature blood cells. If there is no current need for cell replenishment, the blood stem cells remain in a deep sleep to protect themselves from damage to the genome, which can lead to cancer. Blood loss, infections and inflammations act like an alarm clock: immediately, the blood stem cells begin