Les scientifiques de DarwinHealth publient une recherche fondamentale identifiant les mécanismes de régulation contrôlant les états des cellules cancéreuses et la réponse aux médicaments prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.
DarwinHealth Scientists Publish Foundational Research Identifying Regulatory Mechanisms Controlling Cancer Cell States and Drug Response
News provided by
Share this article
Share this article
NEW YORK, Jan. 11, 2021 /PRNewswire/ DarwinHealth, Inc., a New York-based biotechnology and cancer drug discovery company announces the January 11, 2021 online publication in
Cell of a landmark paper, A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity,
1,2 in which scientists from Columbia University and DarwinHealth apply the VIPER (Virtual Inference of Protein activity by Enriched Regulon) analysis algorithm to identify recurrent regulatory networks tumor checkpoints operative across the pancancer subtype continuum.
This research paper, with lead author Dr. Evan Paull, from the Department of Systems Biology at Columbia University, in conjunction with DarwinHealth Co-Founder, Professor Andrea Califano and Chief Scientific Officer, Dr. Mariano Alvarez a
12 gennaio 2021 07:40
Fonte: Adnkronos
#salute-e-benessere
NEW YORK, Jan. 11, 2021 /PRNewswire/ DarwinHealth, Inc., a New York-based biotechnology and cancer drug discovery company announces the January 11, 2021 online publication in Cell of a landmark paper, A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity, 1,2 in which scientists from Columbia University and DarwinHealth apply the VIPER (Virtual Inference of Protein activity by Enriched Regulon) analysis algorithm to identify recurrent regulatory networks tumor checkpoints operative across the pancancer subtype continuum.
This research paper, with lead author Dr. Evan Paull, from the Department of Systems Biology at Columbia University, in conjunction with DarwinHealth Co-Founder, Professor Andrea Califano and Chief Scientific Officer, Dr. Mariano Alvarez and other investigators, presents results and analyses, using a novel Multi-Omics Master-Regulator Analysis framework (MOMA), that validate
E-Mail
NEW YORK, NY (Jan. 11, 2021) Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer s origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer s transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.
The study, published Jan. 11 in
Cell, confirms that Master Regulators provide the molecular logic that integrates the effect of many different and patient-specific mutations to implement the transcriptional state of a specific tumor subtype, thus greatly expanding the fraction of patients who may respond to the same treatment.
the fallout swept around the world today from america s biggest banks, multibillion dollar loss on risky trades. in washington, senator carl levin held a conference call with reporters about jpmorgan s shocking trading losses which could be up to $3 billion and the credit rating agency fitch slapped jp morgan with a drowngrade citing reputational risk. stocks plunged taking other banks down. the boss, america s most well-known banker was taken by surprise. here s jamie dimon one month ago responding to investor questions about bad trades and his risk management unit. it s is a complete tempest in a teapot. sophisticated, complex things. at the end of the day that s our job. invest that portfolio wisely and intelligently over a long period of time to earn income and to offset other exposures we have. well, here he is last night when it turned out that tempest was anything but. these were egregious mistakes, self-inflicted. we re accountable and what happened violates our