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Penn appoints vice dean of AI, more Philly leadership changes
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Penn Medicine appoints first-ever vice dean for artificial intelligence and computing
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Five Penn Medicine experts elected to National Academy of Medicine
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National Academy of Medicine welcomes two new members from Penn
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Pleiotropy analysis, which provides insight on how individual genes result in multiple characteristics, has become increasingly valuable as medicine continues to lean into mining genetics to inform disease treatments. Privacy stipulations, though, make it difficult to perform comprehensive pleiotropy analysis because individual patient data often can t be easily and regularly shared between sites. However, a statistical method called Sum-Share, developed at Penn Medicine, can pull summary information from many different sites to generate significant insights. In a test of the method, published in
Nature Communications, Sum-Share s developers were able to detect more than 1,700 DNA-level variations that could be associated with five different cardiovascular conditions. If patient-specific information from just one site had been used, as is the norm now, only one variation would have been determined.