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Specific genes allow immune T-cells to infiltrate the brain in MS, study finds | 18 genes seen as essential in immune cells movement

Specific genes allow immune T-cells to infiltrate the brain in MS, study finds | 18 genes seen as essential in immune cells movement
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Martin kerschensteinerInstitute of clinical neuroimmunologyClinical neuroimmunology

Researchers identify key regulators involved in genesis of multiple sclerosis lesions

By means of CRISPR screening, LMU researchers have provided the first ever comprehensive molecular characterization of T cell infiltration into the central nervous system of people with MS.

Naoto kawakamiMartin kerschensteinerDanielle ellisInstitute of clinical neuroimmunologyBiomedical center munichClinical neuroimmunologyCenter munichNature neuroscienceMultiple sclerosisCentral nervous systemN vivoNervous system

Key regulators involved in genesis of multiple sclerosis lesions identified

Key regulators involved in genesis of multiple sclerosis lesions identified
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Naoto kawakamiArek kendirliMartin kerschensteinerInstitute of clinical neuroimmunologyBiomedical center munichNature neuroscienceClinical neuroimmunologyCenter munich

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, in which nerve cells are attacked by the patient s own immune system. In many cases, the disease develops into a progressive form, which is characterized by a shift of pathology from the white matter to the gray matter, for instance to the cerebral cortex.

Martin kerschensteinerDoron merklerEmily hendersonDoron merkler university of genevaThomas misgeld technical university of munichUniversity of genevaInstitute for clinical neuroimmunologyClinical neuroimmunologyThomas misgeldTechnical universityMultiple sclerosisCentral nervous systemImmune systemInflammatory diseaseMouse modelNervous system

MS Mouse Study Links Cortical Inflammation to Immune Cell Destruction

4.5 (12) Multiple sclerosis (MS)-associated inflammation in the cerebral cortex the outermost layer of the brain that is involved in cognitive function prompts the destruction of neural connections by specific immune cells, according to a study in a mouse model of MS. These immune cells targeted dendritic spines (nerve cell communication structures) containing abnormally high levels of calcium a dysregulation previously associated with nerve fiber degeneration in MS. Importantly, blocking the activation of these immune cells, called phagocytes, successfully prevented the loss of cerebral cortex synapses (sites of neural communication) in the mice, highlighting that similar approaches may help prevent disease progression in people with MS.

Marta figueiredoMartin kerschensteinerDoron merklerThomas misgeldTechnical university of munichUniversity of lisbonLeiden university medical centerUniversity of genevaBiomedical sciencesClinical neuroimmunologyLudwig maximilians university munichTechnical universityDevelopmental biologyMedical microbiologyInfectious diseasesApplied biology